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Amiodarone and Inderal

Determining the interaction of Amiodarone and Inderal and the possibility of their joint administration.

Check result:

Amiodarone <> Inderal

Relevance: 21.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using amiodarone together with propranolol may lead to increased side effects. Contact your doctor if you experience a reduced heart rate, dizziness, fainting, or headaches. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Additive effects of severe bradycardia, cardiac arrest, and ventricular fibrillation may occur in patients administered amiodarone and beta blockers. The mechanism may be related to additive slowing in AV conduction. In addition, amiodarone may inhibit the first pass hepatic metabolism of some beta blockers. However, a post hoc meta analysis suggests that the addition of amiodarone in patients in whom it is indicated, who are recovering from a recent myocardial infarction, and who are already receiving beta-blockers decreases the incidence of cardiac or arrhythmic death.

MANAGEMENT: Clinical monitoring of patient hemodynamic status and response is recommended.

References

Warren R, Vohra J, Hunt D, Hamer A "Serious interactions of sotalol with amiodarone and flecainide." Med J Aust 152 (1990): 277
Ogunyankin KO, Singh BN "Mortality reduction by antiadrenergic modulation of arrhythmogenic substrate: Significance of combining beta blockers and amiodarone." Am J Cardiol 84 (1999): r76-82
Boutitie F, Boissel JP, Connolly SJ, et al "Amiodarone interaction with beta-blockers - Analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases." Circulation 99 (1999): 2268-75
Leor J, Levartowsky D, Sharon C, Farfel Z "Amiodarone and beta-adrenergic blockers: an interaction with metoprolol but not with atenolol." Am Heart J 16 (1988): 206-7

Amiodarone

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: n.a.

What is Amiodarone?

Inderal

Generic Name: propranolol

Brand name: Inderal LA, Inderal XL, InnoPran XL, Inderal, Hemangeol, InnoPran XL

Synonyms: n.a.

What is Inderal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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