Amiodarone injection and Cardizem LA
Determining the interaction of Amiodarone injection and Cardizem LA and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:The use of amiodarone with dilTIAZem may have additive effects when taken together. While this combination may be useful in some situations contact your doctor if you have a reduced heart rate, dizziness, fainting, or headaches. Your blood pressure may need to be checked more frequently. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR CLOSELY: Amiodarone and diltiazem or verapamil may have additive pharmacodynamic effects when administered concurrently. Sinus arrest, reduced myocardial contractility, and hypotension could result.
MANAGEMENT: The patient's hemodynamic and electrocardiographic status should be closely monitored, especially during amiodarone loading.
- Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23
- Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71
- Lee TH, Friedman PL, Goldman L, Stone PH, Antman EM "Sinus arrest and hypotension with combined amiodarone-diltiazem therapy." Am Heart J 109 (1985): 163-4
- Lee TH, Friedman PL, Goldman L, Stone PH, Antman EM "Sinus arrest and hypotension with combined amiodarone-diltiazem therapy." Am Heart J 109 (1985): 163-4
Generic Name: amiodarone
Brand name: Pacerone, Cordarone, Nexterone
Synonyms: Amiodarone
Generic Name: diltiazem
Brand name: Cardizem LA, Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Tiazac Extended Release Capsules
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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