Amiodarone injection and Indinavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amiodarone and indinavir is not recommended. Taking these drugs together can affect the rhythm of your heart. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with indinavir may significantly increase the plasma concentrations of amiodarone. The proposed mechanism is indinavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of amiodarone. Although clinical data are lacking, the interaction could conceivably lead to serious and/or life-threatening reactions including QT interval prolongation and ventricular arrhythmias such as ventricular tachycardia and torsade de pointes.

MANAGEMENT: The use of indinavir with amiodarone is considered contraindicated by the manufacturer.

Amiodarone injection

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: Amiodarone

What is Amiodarone injection?

Indinavir

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Indinavir?