Amiodarone Injection Solution and Plavix
Determining the interaction of Amiodarone Injection Solution and Plavix and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Rarely, amiodarone has been reported to reduce the effectiveness of clopidogrel. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: According to some of the manufacturers' labeling for amiodarone, ineffective inhibition of platelet aggregation has been reported in association with a potential interaction between clopidogrel and amiodarone. Clopidogrel is a prodrug whose bioactivation is mediated in part by CYP450 2C19 and 3A4. An interaction is theoretically possible on the basis that amiodarone is an inhibitor of CYP450 3A4, while its active metabolite, desethylamiodarone, has been shown to inhibit CYP450 2C19 in vitro.
MANAGEMENT: Until more information is available, it may be advisable to closely monitor the therapeutic efficacy of clopidogrel during concomitant treatment with amiodarone.
- "Product Information. Plavix (clopidogrel)." Bristol-Myers Squibb, Princeton, NJ.
- Ohyama K, Nakajima M, Suzuki M, Shimada N, Yamazaki H, Yokoi T "Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions." Br J Clin Pharmacol 49 (2000): 244-53
- "Product Information. Cordarone (amiodarone)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: amiodarone
Brand name: Pacerone, Cordarone, Nexterone
Synonyms: Amiodarone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amiodarone Injection Solution-Plazomicin
- Amiodarone Injection Solution-Plazomicin Intravenous
- Amiodarone Injection Solution-Plazomicin Sulfate
- Amiodarone Injection Solution-Plecanatide
- Amiodarone Injection Solution-Plegridy
- Amiodarone Injection Solution-Plegridy Pen
- Plavix-Amiodarone Intravenous
- Plavix-Amiodarone Intravenous, Oral
- Plavix-Amiodarone Tablets
- Plavix-Amitiza
- Plavix-Amitriptyline
- Plavix-Amitriptyline and chlordiazepoxide