Amiodarone Intravenous, Oral and Otrexup
Determining the interaction of Amiodarone Intravenous, Oral and Otrexup and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking methotrexate, tell your doctor if you also use amiodarone. You may need dose adjustments or special tests in order to safely take both medications together. If you are receiving this combination you should watch for signs of a skin reaction. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: A case report has suggested that amiodarone may increase the risk of methotrexate toxicity (particularly skin necrosis). The mechanism is unknown and causality could not be definitely determined.
MANAGEMENT: Patients receiving this combination should be monitored for signs of dermatologic reactions (e.g., ulceration, necrosis).
- Reynolds NJ, Jones SK, Crossley M, Harman RR "Methotrexate induced skin necrosis: a drug interaction with amiodarone?" BMJ 299 (1989): 980
Generic Name: amiodarone
Brand name: Pacerone, Cordarone, Nexterone
Synonyms: Amiodarone
Generic Name: methotrexate
Brand name: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep
Synonyms: Otrexup (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amiodarone Intravenous, Oral-Otrexup injection
- Amiodarone Intravenous, Oral-Outgro
- Amiodarone Intravenous, Oral-Ovcon 35
- Amiodarone Intravenous, Oral-Ovidrel
- Amiodarone Intravenous, Oral-Ovidrel injectable
- Amiodarone Intravenous, Oral-Ovidrel Injection
- Otrexup-Amiodarone Tablets
- Otrexup-Amitiza
- Otrexup-Amitriptyline
- Otrexup-Amitriptyline and chlordiazepoxide
- Otrexup-Amitriptyline and perphenazine
- Otrexup-Amitriptyline Hydrochloride