Amiodarone Intravenous, Oral and Zithromax Tri-Pak

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using amiodarone together with azithromycin. Combining these medications can increase the risk of an irregular heart rhythm that is potentially life-threatening. In addition, amiodarone blood levels may be increased by medications like azithromycin, which may lead to the development of serious side effects such as pneumonitis (inflammation of lung tissue), nerve damage, liver injury, thyroid abnormalities, and vision impairment. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or special monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with amiodarone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Amiodarone can cause dose-related prolongation of the QT interval. Coadministration with other agents that can prolong the QT interval such as macrolide antibiotics may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. A case of QT prolongation and increased QT dispersion was reported in a patient three days after oral azithromycin was added to a regimen that included oral amiodarone. The QTc interval increased from 510 to 660 ms, and QT dispersion increased from 58 to 140 ms. The ECG returned to baseline four days after azithromycin was discontinued. In another case, syncope and torsade de pointes in association with QT prolongation developed when intravenous erythromycin was administered to a 76-year-old patient receiving amiodarone therapy, and recurred upon rechallenge. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). Some macrolides such as clarithromycin, erythromycin, and troleandomycin are also potent inhibitors of CYP450 3A4 and may significantly inhibit the metabolism of amiodarone, which is primarily metabolized by the isoenzyme.

MANAGEMENT: The concurrent use of amiodarone with other medications that can prolong the QT interval should generally be avoided unless benefits are anticipated to outweigh the risks. Caution and clinical monitoring are recommended if these agents are prescribed together, especially to patients with underlying risk factors. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath, or syncope.

Amiodarone Intravenous, Oral

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: Amiodarone

What is Amiodarone Intravenous, Oral?

Zithromax Tri-Pak

Generic Name: azithromycin

Brand name: Zithromax, Zmax, AzaSite, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax Tri-Pak, Zithromax Z-Pak, Zithromax IV

Synonyms: Zithromax

What is Zithromax Tri-Pak?