Amiodarone Tablets and Cimetidine Oral Solution
Determining the interaction of Amiodarone Tablets and Cimetidine Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using amiodarone together with cimetidine may increase the effects of amiodarone. Contact your doctor if you experience weakness, slow heart rate, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Amiodarone serum concentrations may be increased during concomitant therapy with cimetidine and toxicity could result. The mechanism is not known but may involve inhibition of amiodarone hepatic metabolism or of uptake by hepatocytes. Given the long half-life of amiodarone, it may take several weeks for the full effect of the interaction to be realized.
MANAGEMENT: If amiodarone and cimetidine must be used concomitantly, monitoring of amiodarone serum concentrations is recommended.
- Hogan C, Landau S, Tepper D, Somberg J "Cimetidine-amiodarone interaction." J Clin Pharmacol 28 (1988): 909
Generic Name: amiodarone
Brand name: Pacerone, Cordarone, Nexterone
Synonyms: Amiodarone
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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