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Amiodarone Tablets and Cytomel

Determining the interaction of Amiodarone Tablets and Cytomel and the possibility of their joint administration.

Check result:

Amiodarone Tablets <> Cytomel

Relevance: 19.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Amiodarone may reduce the effects of liothyronine. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to adjust the dose of liothyronine or prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Amiodarone may reduce the effects of exogenous thyroid hormones. Amiodarone inhibits peripheral conversion of thyroxine (T4) to triiodothyronine (T3) and also contributes inorganic iodine that can result in altered thyroid function tests, hypothyroidism, or hyperthyroidism.

MANAGEMENT: Therapy with amiodarone should be administered cautiously in patients with thyroid dysfunction. Clinical monitoring, including baseline and periodic (every 6 months) laboratory evaluation of thyroid function is recommended during concomitant treatment and for several months after discontinuation of amiodarone, especially in elderly patients. Modification of therapy may be necessary.

References

Figge HL, Figge J "The effects of amiodarone on thyroid hormone function: a review of the physiology and clinical manifestations." J Clin Pharmacol 30 (1990): 588-95
Unger J, Lambert M, Jonckheer MH, Denayer P "Amiodarone and the thyroid: pharmacological, toxic and therapeutic effects." J Intern Med 233 (1993): 435-43
"Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical, Abbott Park, IL.
Enia G, Costante G, Catalano C, Zoccali C, Maggiore Q "Severe hypothyroidism induced by amiodarone in a dialysis patient." Nephron 46 (1987): 206-7
"Product Information. Cordarone (amiodarone)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Figge J, Dluhy RG "Amiodarone-induced elevation of thyroid stimulating hormone in patients receiving levothyroxine for primary hypothyroidism." Ann Intern Med 113 (1990): 553-5
Singh BN, Nademanee K "Amiodarone and thyroid function: clinical implications during antiarrhythmic therapy." Am Heart J 106 (1983): 857-69
Mazonson PD, Williams ML, Cantley LK, Dalldorf FG, Utiger RD, Foster JR "Myxedema coma during long-term amiodarone therapy." Am J Med 77 (1984): 751-4
Martino E, Aghinilombardi F, Bartalena L, Grasso L, Loviselli A, Velluzzi F, Pinchera A, Braverman LE "Enhanced susceptibility to amiodarone-induced hypothyroidism in patients with thyroid autoimmune disease." Arch Intern Med 154 (1994): 2722-6
Harjai KJ, Licata AA "Amiodarone induced hyperthyroidism: a case series and brief review of literature." Pacing Clin Electrophysiol 19 (1996): 1548-54
Harjai KJ, Licata AA "Effects of amiodarone on thyroid function." Ann Intern Med 126 (1997): 63-73
Hauptman PJ, Fyfe B, Mechanick J, Lansman S, Gass A "Fatal hyperthyroidism after amiodarone treatment and total lymphoid irradiation in a heart transplant recipient [published erratum appears in J Heart Lung Transplant 1993 Jul-Aug;12(4):572]." J Heart Lung Transplant 12 (1993): 513-6
Roti E, Minelli R, Gardini E, Bianconi L, Braverman LE "Thyrotoxicosis followed by hypothyroidism in patients treated with amiodarone. A possible consequence of a destructive process in the thyroid." Arch Intern Med 153 (1993): 886-92
"Product Information. Cordarone Intravenous (amiodarone)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Mulligan DC, Mchenry CR, Kinney W, Esselstyn CB, Numann PJ, Roher H, Albertson D "Amiodarone-induced thyrotoxicosis: clinical presentation and expanded indications for thyroidectomy." Surgery 114 (1993): 1114-9
Mehra A, Widerhorn J, Lopresti J, Rahimtoola SH "Amiodarone-induced hyperthyroidism: thyroidectomy under local anesthesia." Am Heart J 122 (1991): 1160-1
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Amiodarone Tablets

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: Amiodarone

What is Amiodarone Tablets?

Cytomel

Generic Name: liothyronine

Brand name: Cytomel, Triostat

Synonyms: n.a.

What is Cytomel?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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