Amiodarone Tablets and Methotrexate Oral Solution
Determining the interaction of Amiodarone Tablets and Methotrexate Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking methotrexate, tell your doctor if you also use amiodarone. You may need dose adjustments or special tests in order to safely take both medications together. If you are receiving this combination you should watch for signs of a skin reaction. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: A case report has suggested that amiodarone may increase the risk of methotrexate toxicity (particularly skin necrosis). The mechanism is unknown and causality could not be definitely determined.
MANAGEMENT: Patients receiving this combination should be monitored for signs of dermatologic reactions (e.g., ulceration, necrosis).
- Reynolds NJ, Jones SK, Crossley M, Harman RR "Methotrexate induced skin necrosis: a drug interaction with amiodarone?" BMJ 299 (1989): 980
Generic Name: amiodarone
Brand name: Pacerone, Cordarone, Nexterone
Synonyms: Amiodarone
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amiodarone Tablets-Methotrexate Oral, Injection
- Amiodarone Tablets-Methotrexate Sodium
- Amiodarone Tablets-Methotrexate Tablets
- Amiodarone Tablets-Methoxsalen
- Amiodarone Tablets-Methoxsalen (Systemic)
- Amiodarone Tablets-Methoxsalen (Topical)
- Methotrexate Oral Solution-Amitiza
- Methotrexate Oral Solution-Amitriptyline
- Methotrexate Oral Solution-Amitriptyline and chlordiazepoxide
- Methotrexate Oral Solution-Amitriptyline and perphenazine
- Methotrexate Oral Solution-Amitriptyline Hydrochloride
- Methotrexate Oral Solution-Amjevita Subcutaneous