Amiodarone Tablets and Mexiletine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amiodarone together with mexiletine can affect the rhythm of your heart. Contact your doctor if you experience tiredness, dizziness, fainting, confusion, tremor, difficulty breathing, and an irregular heartbeat. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration of amiodarone and mexiletine has been associated with an isolated case of torsade de pointes. The mechanism of interaction is unknown, as mexiletine has not been shown to prolong the QT interval of the electrocardiogram. In fact, mexiletine has been used in the treatment of torsade de pointes. A study of patients with supraventricular tachyarrhythmias treated with a combination of amiodarone and mexiletine or mexiletine alone found no evidence of a pharmacokinetic interaction. Some investigators have also reported on the safe and effective use of the combination.

MANAGEMENT: In general, the concurrent use of amiodarone with other antiarrhythmic agents should be reserved for patients with life-threatening ventricular arrhythmias who are incompletely responsive to a single agent or to amiodarone alone. If adding or transferring to amiodarone, the dosages of previously administered agents should be reduced by 30% to 50% several days after the addition of amiodarone, when onset of arrhythmia suppression should occur. The continued need for other antiarrhythmic agents should be evaluated after the effects of amiodarone have been established, and discontinuation should generally be attempted. If the combination is continued, patients should be monitored for adverse effects including conduction disturbances and exacerbation of tachyarrhythmias. In amiodarone-treated patients who require additional antiarrhythmic agents, the initial dosage of such agents should be approximately one-half the usual recommended dosage.

Amiodarone Tablets

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: Amiodarone

What is Amiodarone Tablets?

Mexiletine

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: n.a.

What is Mexiletine?