Amitriptyline and Guanfacine Tablets
Determining the interaction of Amitriptyline and Guanfacine Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using amitriptyline together with guanFACINE can decrease the effects of guanFACINE. Talk with your doctor before using amitriptyline and guanFACINE together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: One case report suggests that tricyclic antidepressants may decrease the antihypertensive effect of guanfacine. The mechanism is unknown.
MANAGEMENT: The patient's blood pressure should be monitored during concomitant therapy and after discontinuation or dose change of the antidepressant. An alternative antihypertensive (e.g., beta adrenergic blocking agent, diuretic) may be considered.
- Buckley M, Feely J "Antagonism of antihypertensive effect of guanfacine by tricyclic antidepressants." Lancet 337 (1991): 1173-4
Generic Name: amitriptyline
Brand name: Vanatrip, Elavil, Endep
Synonyms: n.a.
Generic Name: guanfacine
Brand name: Intuniv, Tenex
Synonyms: Guanfacine, GuanFACINE
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amitriptyline-Guanidine
- Amitriptyline-Guar Gum
- Amitriptyline-Guiadrine DX
- Amitriptyline-Guiatex PE
- Amitriptyline-Gumsol
- Amitriptyline-Guna-Beta-Estradiol
- Guanfacine Tablets-Amitriptyline and chlordiazepoxide
- Guanfacine Tablets-Amitriptyline and perphenazine
- Guanfacine Tablets-Amitriptyline Hydrochloride
- Guanfacine Tablets-Amjevita Subcutaneous
- Guanfacine Tablets-Amlobenz
- Guanfacine Tablets-Amlodipine