Amitriptyline Hydrochloride and Riluzole Suspension
Determining the interaction of Amitriptyline Hydrochloride and Riluzole Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Amitriptyline may increase the serum concentration of riluzole. Riluzole is metabolized by the CYP1A2 isoenzyme. Amitriptyline inhibits this particular isoenzyme, possibly decreasing the elimination rate of riluzole. The clinical significance of this interaction is not known. During coadministration, the patient should be more closely monitored for altered clinical effect.
- "Product Information. Rilutek (riluzole)." Rhone-Poulenc Rorer, Collegeville, PA.
Generic Name: amitriptyline
Brand name: Vanatrip, Elavil, Endep
Synonyms: Amitriptyline
Generic Name: riluzole
Brand name: Rilutek, Tiglutik
Synonyms: Riluzole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amitriptyline Hydrochloride-Riluzole Tablets
- Amitriptyline Hydrochloride-RimabotulinumtoxinB
- Amitriptyline Hydrochloride-Rimabotulinumtoxinb Intramuscular
- Amitriptyline Hydrochloride-Rimactane
- Amitriptyline Hydrochloride-Rimantadine
- Amitriptyline Hydrochloride-Rimantadine Hydrochloride
- Riluzole Suspension-Amjevita Subcutaneous
- Riluzole Suspension-Amlobenz
- Riluzole Suspension-Amlodipine
- Riluzole Suspension-Amlodipine and atorvastatin
- Riluzole Suspension-Amlodipine and Atorvastatin Tablets
- Riluzole Suspension-Amlodipine and benazepril