Drug search by name

Amitriptyline Hydrochloride and Tolazamide

Determining the interaction of Amitriptyline Hydrochloride and Tolazamide and the possibility of their joint administration.

Check result:

Amitriptyline Hydrochloride <> Tolazamide

Relevance: 08.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking amitriptyline, tell your doctor if you also use TOLAZamide. You may need dose adjustments or special tests in order to safely take both medications together. You should be instructed about the need for regular monitoring of blood glucose levels and be aware of symptoms of low blood sugar such as headache, dizziness, drowsiness, nausea, hunger, and sweating. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Case reports suggest that tricyclic antidepressants may increase the hypoglycemic effects of sulfonylureas. The mechanism is unknown. Causality has not been definitely determined and one small trial demonstrated no pharmacokinetic changes with amitriptyline and tolbutamide.

MANAGEMENT: Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients.

References

Zogno MG, Tolfo L, Draghi E "Hypoglycemia caused by maprotiline in a patient taking oral antidiabetics." Ann Pharmacother 28 (1994): 406
True BL, Perry PJ, Burns EA "Profound hypoglycemia with the addition of a tricyclic antidepressant to maintenance sulfonylurea therapy." Am J Psychiatry 144 (1987): 1220-1
Sherman KE, Bornemann M "Amitriptyline and asymptomatic hypoglycemia." Ann Intern Med 109 (1988): 683-4
Pond SM, Graham GG, Birkett DJ, Wade DN "Effects of tricyclic antidepressants on drug metabolism." Clin Pharmacol Ther 18 (1975): 191-9

Amitriptyline Hydrochloride

Generic Name: amitriptyline

Brand name: Vanatrip, Elavil, Endep

Synonyms: Amitriptyline

What is Amitriptyline Hydrochloride?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions