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Amlodipine and Atorvastatin Tablets and Dabigatran Etexilate

Determining the interaction of Amlodipine and Atorvastatin Tablets and Dabigatran Etexilate and the possibility of their joint administration.

Check result:

Amlodipine and Atorvastatin Tablets <> Dabigatran Etexilate

Relevance: 13.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of dabigatran etexilate with atorvastatin resulted in an approximately 20% decrease in dabigatran plasma concentrations, which is not considered clinically significant. No dosage adjustment is recommended for dabigatran etexilate. Conversely, dabigatran had no effect on atorvastatin systemic exposure or that of its metabolites.

References

"Product Information. Pradaxa (dabigatran)." Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Pradax (dabigatran)." Boehringer Ingelheim (Canada) Ltd, Burlington, IA.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Amlodipine and Atorvastatin Tablets

Generic Name: amlodipine / atorvastatin

Brand name: Caduet

Synonyms: Amlodipine and atorvastatin, Amlodipine and Atorvastatin

What is Amlodipine and Atorvastatin Tablets?

Dabigatran Etexilate

Generic Name: dabigatran

Brand name: Pradaxa

Synonyms: Dabigatran

What is Dabigatran Etexilate?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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