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Amlodipine and Atorvastatin Tablets and Revlimid

Determining the interaction of Amlodipine and Atorvastatin Tablets and Revlimid and the possibility of their joint administration.

Check result:

Amlodipine and Atorvastatin Tablets <> Revlimid

Relevance: 13.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using atorvastatin together with lenalidomide may increase the risk of a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. The risk is greatest if you are elderly or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment with atorvastatin or similar medications, especially if these symptoms are accompanied by fever or dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: The risk of rhabdomyolysis may be increased during coadministration of lenalidomide with HMG-CoA reductase inhibitors (statins). The mechanism is unknown but may involve additive pharmacodynamic effects. The European Medicines Agency Pharmacovigilance Risk Assessment Committee (PRAC) evaluated 23 cases of rhabdomyolysis associated with lenalidomide; concomitant use of statins occurred in 4 cases. All cases were considered serious and patients recovered after both drugs were discontinued. Rhabdomyolysis occurred within 5, 14 and 19 days after initiation of lenalidomide in 3 cases and within 8 days after increased lenalidomide dosage in the fourth case.

MANAGEMENT: European product labeling recommends caution and increased clinical and biological monitoring if lenalidomide is used in combination with statins, especially during the first several weeks of treatment. All patients treated with statins should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.

References

EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
EMA. European Medicines Agency. Committee for Medicinal Products for Human Use (CHMP) "Revlimid. Available from: URL: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Conclusion/human/000717/WC500160159.pdf." ([2013 Sept 19]):
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
EMA. European Medicines Agency. PRAC. Pharmacovigilance Risk Assessment Committee "Pharmacovigilance Risk Assessment Committee (PRAC) Minutes of the meeting on 2-5 September 2013. Available from: URL: http://www.ema.europa.eu/docs/en_GB/document_library/Minutes/2013/10/WC500152672.pdf." ([2013 Oct 10]):

Amlodipine and Atorvastatin Tablets

Generic Name: amlodipine / atorvastatin

Brand name: Caduet

Synonyms: Amlodipine and atorvastatin, Amlodipine and Atorvastatin

What is Amlodipine and Atorvastatin Tablets?

Revlimid

Generic Name: lenalidomide

Brand name: Revlimid

Synonyms: n.a.

What is Revlimid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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