Amlodipine and Olmesartan Medoxomil and Cobolin-M injection

• Generic Name: amlodipine / olmesartan
• Dosage Forms: tablet, film coated
• Other Brand Names: Azor

Amlodipine is a calcium channel blocker. Olmesartan is an angiotensin II receptor blocker (ARB).

Amlodipine and olmesartan is a combination medicine used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.

Amlodipine and olmesartan may also be used for purposes not listed in this medication guide.

• Generic Name: cyanocobalamin
• Dosage Forms: n.a.
• Other Brand Names:

  Cobolin-M, Depo-Cobolin, Vitamin B12, Vitamin B-12, B-12 Dots, Nascobal, Cobal 1000

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.