Amlodipine and perindopril and Sweet vernal/orchard/perennial rye/timothy/kentucky blue grass mixed pollen allergen extract Sublingual
Determining the interaction of Amlodipine and perindopril and Sweet vernal/orchard/perennial rye/timothy/kentucky blue grass mixed pollen allergen extract Sublingual and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using mixed grass pollens allergen extract together with perindopril may not be advisable. Treatment with perindopril may increase the severity of allergic reactions that can sometimes occur during immunotherapy with mixed grass pollens allergen extract. Potentially life-threatening or fatal reactions may occur. Talk to your doctor if you have any questions or concerns. Stop using mixed grass pollens allergen extract, administer epinephrine, and seek immediate medical attention if signs and symptoms of an allergic reaction develop such as trouble breathing, swallowing, or speaking; throat tightness or swelling; dizziness, lightheadedness, or fainting; rapid or weak heartbeat; severe stomach cramps or pain; vomiting or diarrhea; and/or severe flushing or itching. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Concomitant use of angiotensin converting enzyme (ACE) inhibitors may pose a greater risk of more serious systemic reactions, including anaphylaxis, to allergen immunotherapy. The proposed mechanism is inhibition by ACE inhibitors of the degradation of bradykinin, an inflammatory vasoactive peptide that causes vasodilation of blood vessels and increased vascular permeability of the postcapillary venules. Elevated bradykinin levels have been associated with ACE inhibitor-related angioedema of the face, extremities, lips, tongue, glottis, and/or larynx. Two patients who were undergoing desensitizing treatment with hymenoptera venom during ACE inhibitor therapy sustained life-threatening anaphylactoid reactions, which were avoided when ACE inhibitors were temporarily withheld but reappeared upon inadvertent rechallenge.
MANAGEMENT: Immunotherapy with allergenic extracts may not be appropriate in patients receiving ACE inhibitors due to the potential for more serious systemic reactions. Close monitoring is advised if coadministration is required.
- "Product Information. Vasotec (enalapril)." Merck & Co, Inc, West Point, PA.
- "Product Information. Oralair (mixed grass pollens allergen extract)." Greer Laboratories Inc, Lenoir, NC.
Generic Name: amlodipine / perindopril
Brand name: Prestalia
Synonyms: Perindopril and Amlodipine
Generic Name: mixed grass pollens allergen extract
Brand name: Oralair
Synonyms: Mixed grass pollens allergen extract, Grass Pollen Allergen Extract (5 Grass Extract)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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