Amlodipine, hydrochlorothiazide, and valsartan and Ivabradine
Determining the interaction of Amlodipine, hydrochlorothiazide, and valsartan and Ivabradine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Both ivabradine and amLODIPine can slow the heart rate, and using them together may increase this effect and cause conduction problems and irregular heart rhythm. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if you develop significant decreases in heart rate or symptoms such as dizziness, lightheadedness, fainting, or low blood pressure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of ivabradine with other drugs that can slow the heart rate such as beta-blockers, calcium channel blockers, and digitalis may increase the risk of excessive bradycardia or other conduction disturbances. Non-cardiac drugs that may also cause bradycardia include atazanavir, fingolimod, lacosamide, lithium, mefloquine, succinylcholine, thalidomide, H2-receptor antagonists, tricyclic antidepressants, and anticholinesterase or cholinergic agents.
MANAGEMENT: Caution is advised when ivabradine is prescribed with other bradycardic drugs. Heart rate should be closely monitored, and the dosage of ivabradine adjusted accordingly. Patients should be advised to report significant decreases in heart rate or symptoms such as dizziness, lightheadedness, fatigue, and hypotension.
- "Product Information. Corlanor (ivabradine)." Amgen USA, Thousand Oaks, CA.
Generic Name: amlodipine / hydrochlorothiazide / valsartan
Brand name: Exforge HCT
Synonyms: Amlodipine, Valsartan, and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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