Amlodipine, hydrochlorothiazide, and valsartan and Octreotide
Determining the interaction of Amlodipine, hydrochlorothiazide, and valsartan and Octreotide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Octreotide can sometimes slow your heart rate, and using it with amLODIPine may further increase that effect. This can lead to an excessively slow heartbeat, heart block, low pulse, headache, dizziness, or fainting. Let your doctor know if you experience any of these symptoms or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Somatostatin analogs (e.g., octreotide, lanreotide) can decrease heart rate and may potentiate the bradycardic effects of drugs like beta-blockers, calcium channel blockers, digitalis glycosides, and certain antiarrhythmic agents (e.g., class I antiarrhythmics, adenosine, amiodarone). Octreotide has commonly been associated with bradycardia (less than 50 bpm), conduction abnormalities, and arrhythmias in acromegalic patients. Occasional cases of sinus bradycardia and ventricular tachycardia have also been reported with lanreotide.
MANAGEMENT: Caution is advised if somatostatin analogs are prescribed with agents that exhibit bradycardic effects, including ophthalmic formulations of beta-blockers. Heart rate and blood pressure should be monitored.
- "Product Information. Sandostatin (octreotide)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Somatuline Depot (lanreotide)." Ipsen Inc, Milford, MA.
Generic Name: amlodipine / hydrochlorothiazide / valsartan
Brand name: Exforge HCT
Synonyms: Amlodipine, Valsartan, and Hydrochlorothiazide
Generic Name: octreotide
Brand name: Sandostatin, Sandostatin LAR Depot
Synonyms: Octreotide (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amlodipine, hydrochlorothiazide, and valsartan-Octreotide Acetate
- Amlodipine, hydrochlorothiazide, and valsartan-Octreotide injection
- Amlodipine, hydrochlorothiazide, and valsartan-Octreotide Injection, Intramuscular
- Amlodipine, hydrochlorothiazide, and valsartan-Octreotide Long-Acting Injection
- Amlodipine, hydrochlorothiazide, and valsartan-Ocu-Carpine
- Amlodipine, hydrochlorothiazide, and valsartan-Ocu-Chlor
- Octreotide-Amlodipine, Valsartan, and Hydrochlorothiazide
- Octreotide-Ammonium Chloride
- Octreotide-Ammonul
- Octreotide-Amnesteem
- Octreotide-Amobarbital
- Octreotide-Amoclan