Amnesteem and Coumadin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with ISOtretinoin may decrease the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

MONITOR: Limited data suggest that isotretinoin may reduce the hypoprothrombinemic effect of warfarin. The mechanism of interaction is unknown. A case report describes a 61-year-old patient stabilized on warfarin 2.5 mg/day for 2 to 3 years who experienced a decreased INR following initiation of cefpodoxime proxetil (200 mg orally twice a day) and isotretinoin (30 mg orally daily) for a facial eruption due to Klebsiella infection. An increase in the warfarin dosage to 3.75 mg/day was necessary to maintain his INR within therapeutic range. The INR remained stable at the new dosage after completion of cefpodoxime therapy but increased when isotretinoin was discontinued after 40 days. Warfarin dosage was subsequently reduced to the previous level.

MANAGEMENT: Until further information is available, INR should be monitored more closely whenever isotretinoin is added to or withdrawn from therapy, and the warfarin dosage adjusted as necessary. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical data are lacking.

Amnesteem

Generic Name: isotretinoin

Brand name: Absorica, Amnesteem, Claravis, Myorisan, Sotret, Zenatane, Accutane

Synonyms: n.a.

What is Amnesteem?

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?