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Amoxapine and Quin-G

Determining the interaction of Amoxapine and Quin-G and the possibility of their joint administration.

Check result:

Amoxapine <> Quin-G

Relevance: 13.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using amoxapine together with quiNIDine. This can cause uneven heartbeats, extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, feeling light-headed, fainting, seizure (convulsions), or coma. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Quinidine may markedly increase the serum levels of some tricyclic antidepressants (TCAs). The mechanism is related to inhibition of CYP450 2D6 metabolism. Extensive metabolizers of debrisoquine may be at greater risk of developing significant TCA toxicity. Desipramine, nortriptyline, and imipramine have been specifically implicated in this interaction. In addition, both quinidine and TCAs may cause prolongation of the QT interval which could result in torsades de pointes.

MANAGEMENT: If possible, this combination should be avoided. Close clinical, electrocardiographic, and laboratory monitoring is recommended for patients who do receive these drugs concurrently. Patients should be advised to promptly notify their physicians if they experience irregular heartbeats or palpitations, syncope, drowsiness, confusion, weakness, or seizures.

References

Brosen K, Gram LF "Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine." Eur J Clin Pharmacol 37 (1989): 155-60
Roos JC "Cardiac effects of antidepressant drugs. A comparison of the tricyclic antidepressants and fluvoxamine." Br J Clin Pharmacol 15 Suppl 3 (1983): s439-45
Caporaso NE, Shaw GL "Clinical implications of the competitive inhibition of the debrisoquin-metabolizing isozyme by quinidine." Arch Intern Med 151 (1991): 1985-92
Steiner E, Dumont E, Spina E, Dahlqvist R "Inhibition of desipramine 2-hydroxylation by quinidine and quinine." Clin Pharmacol Ther 43 (1987): 577-81
von Moltke LL, Greenblatt DJ, Cotreau-Bibbo MM, Duan SX, Harmatz JS, Shader RI "Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo." J Pharmacol Exp Ther 268 (1994): 1278-83

Amoxapine

Generic Name: amoxapine

Brand name: Asendin

Synonyms: n.a.

What is Amoxapine?

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quin-G?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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