Amoxicillin, clarithromycin, and lansoprazole and Valproic Acid Syrup
Determining the interaction of Amoxicillin, clarithromycin, and lansoprazole and Valproic Acid Syrup and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before using valproic acid, tell your doctor if you also use clarithromycin. This combination may cause restlessness, seizures, tremors, slurred speech, staggering walk, and feeling light-headed or fainting. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests in order to safely take both medications together. Avoid driving until you know how the medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: A single case has been reported in which a patient developed seizures associated with elevated blood valproate levels after erythromycin was added to a stable valproate regimen. The seizures and elevated valproate levels resolved after both drugs were withheld. The patient subsequently tolerated her usual valproate dosage. The mechanism is suspected to be inhibition of the hepatic metabolism of valproate.
MANAGEMENT: While more data are needed, clinicians are encouraged to be aware that this interaction is possible when macrolide antimicrobial agents and valproate are coadministered. Patients should be advised to notify their physicians if they experience weakness, fatigue, confusion, ataxia, increased seizures, nausea, or vomiting.
- Redington K, Wells C, Petito F "Erythromycin and valproate interaction." Ann Intern Med 116 (1992): 877-8
Generic Name: amoxicillin / clarithromycin / lansoprazole
Brand name: Prevpac
Synonyms: Lansoprazole, Amoxicillin, and Clarithromycin
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic acid, Valproic Acid and Derivatives
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amoxicillin, clarithromycin, and lansoprazole-Valrubicin
- Amoxicillin, clarithromycin, and lansoprazole-Valrubicin Intravesical
- Amoxicillin, clarithromycin, and lansoprazole-Valsartan
- Amoxicillin, clarithromycin, and lansoprazole-Valsartan and Hydrochlorothiazide
- Amoxicillin, clarithromycin, and lansoprazole-Valsartan Capsules
- Amoxicillin, clarithromycin, and lansoprazole-Valsartan Tablets
- Valproic Acid Syrup-Amoxicillin, clarithromycin, and omeprazole
- Valproic Acid Syrup-Amoxicillin/Clavulanate Chewable Tablets
- Valproic Acid Syrup-Amoxicillin/Clavulanate Extended-Release Tablets
- Valproic Acid Syrup-Amoxicillin/Clavulanate Suspension
- Valproic Acid Syrup-Amoxicillin/Clavulanate Tablets
- Valproic Acid Syrup-Amoxicot