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Amphadase and Vivacaine

Determining the interaction of Amphadase and Vivacaine and the possibility of their joint administration.

Check result:
Amphadase <> Vivacaine
Relevance: 11.04.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

When hyaluronidase is added to a local anesthetic, the local anesthetic solution undergoes increased absorption, resulting in a shorter duration of action and possible increased frequency of systemic reactions. The clinical significance is unknown. It may be advisable to monitor the patient for altered anesthetic efficacy and side effects.

References
  • "Product Information. Vitrase (hyaluronidase)." Bausch and Lomb, Rochester, NY.
Amphadase

Generic Name: hyaluronidase

Brand name: Amphadase, Hylenex, Vitrase, Wydase, Hydase

Synonyms: n.a.

Vivacaine

Generic Name: bupivacaine / epinephrine

Brand name: Marcaine/Epinephrine, Marcaine/Epinephrine PF, Sensorcaine-MPF/EPINEPHrine, Sensorcaine/EPINEPHrine

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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