Amphotericin B Cholesteryl Sulfate Complex and Clonidine and Chlorthalidone
Determining the interaction of Amphotericin B Cholesteryl Sulfate Complex and Clonidine and Chlorthalidone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using amphotericin B cholesteryl sulfate together with chlorthalidone may increase the risk of a condition called hypokalemia, or low blood potassium. In severe cases, it can lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. Let your doctor know if you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid heart beat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of amphotericin and potassium-wasting diuretics may result in increased risk of hypokalemia due to additive effects.
MANAGEMENT: Patients receiving diuretics with amphotericin should be monitored closely for development of hypokalemia. Potassium supplementation may be necessary. Patients should be advised to notify their physician if they experience signs of electrolyte disturbances such as weakness, lethargy, and muscle pains or cramps.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: amphotericin b cholesteryl sulfate
Brand name: Amphotec
Synonyms: n.a.
Generic Name: chlorthalidone / clonidine
Brand name: Clorpres
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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