Amphotericin B (Conventional) and Micafungin Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using amphotericin B together with micafungin. Combining these medications may increase the blood levels and effects of amphotericin B. This may increase the risk and/or severity of side effects such as fever, chills, nausea, vomiting, loss of appetite, difficulty breathing, muscle pain or cramps, low blood pressure, irregular heartbeat, convulsions, ringing in the ears, hearing loss, visual disturbances, and kidney damage. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant use of micafungin and amphotericin B may increase systemic exposure to amphotericin. The mechanism is unknown. Coadministration resulted in a 30% increase in amphotericin exposure. Micafungin pharmacokinetics were not affected.

MANAGEMENT: The European manufacturers recommend that these drugs should only be coadministered if the potential benefits outweigh the risks. Patients should be monitored for amphotericin toxicity.

Amphotericin B (Conventional)

Generic Name: amphotericin b

Brand name: Fungizone, Fungizone For Tissue Culture, Amphocin

Synonyms: Amphotericin B

What is Amphotericin B (Conventional)?

Micafungin Intravenous

Generic Name: micafungin

Brand name: Mycamine

Synonyms: Micafungin

What is Micafungin Intravenous?