Amphotericin B (Conventional) and Pentamidine (Oral Inhalation)
Determining the interaction of Amphotericin B (Conventional) and Pentamidine (Oral Inhalation) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using pentamidine together with amphotericin B can be harmful to the kidneys. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The possible nephrotoxic side effects of pentamidine and amphotericin may be additive.
MANAGEMENT: Serum creatinine and BUN should be monitored closely during therapy with these two agents.
- Antoniskis D, Larsen RA "Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine." Antimicrob Agents Chemother 34 (1990): 470-2
- "Product Information. Abelcet (amphotericin B)." Liposome Company Inc, The, Princeton, NJ.
Generic Name: amphotericin b
Brand name: Fungizone, Fungizone For Tissue Culture, Amphocin
Synonyms: Amphotericin B
Generic Name: pentamidine
Brand name: Nebupent, Pentam 300, Pentam
Synonyms: Pentamidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amphotericin B (Conventional)-Pentamidine (Systemic)
- Amphotericin B (Conventional)-Pentamidine Inhalation, oral/nebulization
- Amphotericin B (Conventional)-Pentamidine Injection
- Amphotericin B (Conventional)-Pentamidine Isethionate
- Amphotericin B (Conventional)-Pentamycetin Ophthalmic Solution 0.25%
- Amphotericin B (Conventional)-Pentamycetin Ophthalmic Solution 0.5%
- Pentamidine (Oral Inhalation)-Amphotericin B (Lipid Complex)
- Pentamidine (Oral Inhalation)-Amphotericin B Cholesteryl Sulfate Complex
- Pentamidine (Oral Inhalation)-Amphotericin b cholesteryl sulfate complex Intravenous
- Pentamidine (Oral Inhalation)-Amphotericin b Intravenous, Injection
- Pentamidine (Oral Inhalation)-Amphotericin b lipid complex Intravenous, Injection
- Pentamidine (Oral Inhalation)-Amphotericin B liposomal