Amphotericin b lipid complex Intravenous, Injection and Flucytosine
Determining the interaction of Amphotericin b lipid complex Intravenous, Injection and Flucytosine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using flucytosine together with amphotericin B lipid complex may increase the effects of flucytosine. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, and yellowing of the skin or eyes, If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of amphotericin B may potentiate the toxicity of flucytosine. The exact mechanism of interaction is unknown but may involve increased cellular uptake of flucytosine or impairment of its renal excretion. The risk of gastrointestinal, hepatic, and hematologic toxicity may be increased.
MANAGEMENT: Caution is advised if flucytosine must be used in patients who are receiving treatment with amphotericin. Blood levels should be monitored and the dose or dosing interval should be adjusted to maintain flucytosine concentrations below 100 mcg/mL.
- Kauffman CA, Frame PT "Bone marrow toxicity associated with 5-fluorocytosine therapy." Antimicrob Agents Chemother 11 (1977): 244-7
- "Product Information. Fungizone (amphotericin B)." Apothecon Inc, Plainsboro, NJ.
- Bryan CS, McFarland JA "Cryptococcal meningitis: fatal marrow aplasia from combined therapy." JAMA 239 (1978): 1068-9
- "Product Information. Abelcet (amphotericin B)." Liposome Company Inc, The, Princeton, NJ.
- "Product Information. Ancobon (flucytosine)." Roche Laboratories, Nutley, NJ.
Generic Name: amphotericin b lipid complex
Brand name: Abelcet
Synonyms: Amphotericin B (Lipid Complex), Amphotericin B lipid complex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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