Amphotericin b liposome Intravenous and Digoxin Oral Solution
Determining the interaction of Amphotericin b liposome Intravenous and Digoxin Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using digoxin together with amphotericin B liposomal may decrease your potassium blood levels. Your potassium levels should be replenished, and blood potassium levels should be checked frequently during therapy. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Although amphotericin does not alter the pharmacokinetics of digoxin, it may increase the risk of toxicity. The mechanism is reduction of serum potassium via renal potassium wasting.
MANAGEMENT: The patient's potassium should be replenished, and serum potassium levels should be checked frequently during therapy. Electrocardiographic monitoring may also be indicated.
- "Product Information. Abelcet (amphotericin B)." Liposome Company Inc, The, Princeton, NJ.
- Miller R, Bates J "Amphotericin B toxicity." Ann Intern Med 71 (1969): 1089-95
- Cushard WG, Kohanim M, Lantis LR "Blastomycosis of bone." J Bone Joint Surg Am 51A (1969): 704-12
Generic Name: amphotericin b liposomal
Brand name: Ambisome
Synonyms: Amphotericin B liposomal, Amphotericin B (Liposomal)
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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