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Ampicillin and Lariam

Determining the interaction of Ampicillin and Lariam and the possibility of their joint administration.

Check result:

Ampicillin <> Lariam

Relevance: 02.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Plasma concentrations of mefloquine are significantly higher in the presence of ampicillin, after single oral doses. The mechanism of this interaction may be due to a reduction in enterohepatic recycling or a decrease in the volume of distribution of mefloquine. The clinical significance is unknown.

References

Karbwang J, Bangchang KN, Back DJ, Bunnag D "Effect of ampicillin on mefloquine pharmacokinetics in Thai males." Eur J Clin Pharmacol 40 (1991): 631-3

Ampicillin

Generic Name: ampicillin

Brand name: Principen, Omnipen-N, Totacillin-N, Ampicillin

Synonyms: n.a.

What is Ampicillin?

Lariam

Generic Name: mefloquine

Brand name: Lariam

Synonyms: n.a.

What is Lariam?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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