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Ampicillin and sulbactam and Chloroquine

Determining the interaction of Ampicillin and sulbactam and Chloroquine and the possibility of their joint administration.

Check result:

Ampicillin and sulbactam <> Chloroquine

Relevance: 22.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Chloroquine may interfere with the absorption of ampicillin and reduce its effectiveness. To minimize the risk of an interaction, you should try to separate the dosing of these medications by at least 2 hours. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Concomitant administration of chloroquine may delay as well as decrease the gastrointestinal absorption of ampicillin. The exact mechanism of interaction is unknown, but may involve slowing of gastric emptying and enhancement of gut motility induced by chloroquine. In seven healthy volunteers, coadministration of a single 1 gram oral dose each of ampicillin and chloroquine resulted in an approximately 30% decrease in both the rate and extent of ampicillin absorption compared to administration of ampicillin alone. However, the bioavailability of ampicillin from the prodrug, bacampicillin, is reportedly not affected by chloroquine.

MANAGEMENT: To avoid potentially subtherapeutic plasma concentrations of ampicillin during coadministration with chloroquine, the drugs should be administered at least 2 hours apart.

References

Ali HM "Reduced ampicillin bioavailability following oral coadministration with chloroquine." J Antimicrob Chemother 15 (1985): 781-4
"Product Information. Aralen (chloroquine)." Sanofi Winthrop Pharmaceuticals, New York, NY.

Ampicillin and sulbactam

Generic Name: ampicillin / sulbactam

Brand name: Unasyn, Unasyn ADD-Vantage

Synonyms: Ampicillin and Sulbactam

What is Ampicillin and sulbactam?

Chloroquine

Generic Name: chloroquine

Brand name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Chloroquine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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