Ampicillin and sulbactam Injection and Heparin and Sodium Chloride
Determining the interaction of Ampicillin and sulbactam Injection and Heparin and Sodium Chloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Case reports have suggested that intravenous penicillins may intensify the effect of heparin by inhibition of platelet aggregation; however, causality has not been clearly determined. Patients should be monitored for bleeding problems. Protamine sulfate may be useful for clinically important bleeding.
- Wisloff F, Larsen JP, Dahle A, Lie M, Godal HC "Effect of prophylactic high-dose treatment with ampicillin and cloxacillin on bleeding time and bleeding in patients undergoing elective vascular surgery." Scand J Haematol 31 (1983): 97-101
- Tabernero JM, Corbacho RL, Sanchez S, et al "Effects of carbenicillin on blood coagulation: a study in patients with chronic renal failure." Clin Nephrol 11 (1979): 31-4
- Brown CH, Natelson EA, Bradshaw W, Williams TW, Alfrey CP "The hemostatic defect produced by carbenicillin." N Engl J Med 291 (1974): 265-70
Generic Name: ampicillin / sulbactam
Brand name: Unasyn, Unasyn ADD-Vantage
Synonyms: Ampicillin and sulbactam, Ampicillin and Sulbactam
Generic Name: heparin
Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush
Synonyms: Heparin Injection, Heparin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ampicillin and sulbactam Injection-Heparin flush
- Ampicillin and sulbactam Injection-Heparin Intravenous, Subcutaneous
- Ampicillin and sulbactam Injection-Heparin Lock flush
- Ampicillin and sulbactam Injection-Heparin Lock Flush Solution
- Ampicillin and sulbactam Injection-Heparin Sodium
- Ampicillin and sulbactam Injection-Heparin, Concentrate
- Heparin and Sodium Chloride-Ampicillin Capsules
- Heparin and Sodium Chloride-Ampicillin injection
- Heparin and Sodium Chloride-Ampicillin Injection Solution
- Heparin and Sodium Chloride-Ampicillin Oral Suspension
- Heparin and Sodium Chloride-Ampicillin Sodium
- Heparin and Sodium Chloride-Ampicillin Sodium and Sulbactam Sodium