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Ampicillin Injection Solution and Plazomicin Intravenous

Determining the interaction of Ampicillin Injection Solution and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Ampicillin Injection Solution <> Plazomicin Intravenous

Relevance: 06.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ampicillin may reduce the effects of plazomicin if they are mixed in the same IV container or line. When used together, they typically should be administered separately. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Ampicillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is significant only in patients with renal failure or if the agents are mixed in the same IV container or line. Lower serum aminoglycoside levels may be seen, and dosage adjustments may be necessary.

MANAGEMENT: Ampicillin and aminoglycosides should be administered separately during combined therapy.

References

Pickering LK, Rutherford I "Effect of concentration and time upon inactivation of tobramycin, gentamicin, netilmicin and amikacin by azlocillin, carbenicillin, mecillinam, mezlocillin and piperacillin." J Pharmacol Exp Ther 217 (1981): 345-9
Russo ME, Atkin-Thor E "Gentamicin and ticarcillin in subjects with end-stage renal disease." Clin Nephrol 15 (1981): 175-80
Viollier AF, Standiford HC, Drusano GL, Tatem BA, Moody MR, Schimpff SC "Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin." J Antimicrob Chemother 15 (1985): 597-606
"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Kradjan WA, Burger R "In vivo inactivation of gentamycin by carbenicillin and ticarcillin." Arch Intern Med 140 (1980): 1668-70
Halstenson CE, Hirata CA, Heim-Duthoy KL, Abraham PA, Matzke GR "Effect of concomitant administration of piperacillin on the dispositions of netilmicin and tobramycin in patients with end-stage renal disease." Antimicrob Agents Chemother 34 (1990): 128-33
Riff LJ, Jackson GG "Laboratory and clinical conditions for gentamicin inactivation by carbenicillin." Arch Intern Med 130 (1972): 887-91
Henderson JL, Polk RE, Kline BJ "In vitro inactivation of gentamicin, tobramycin, and netilmicin by carbenicillin, azlocillin, or mezlocillin." Am J Hosp Pharm 38 (1981): 1167-70
Davies M, Morgan JR, Anand C "Interactions of carbenicillin and ticarcillin with gentamicin." Antimicrob Agents Chemother 7 (1975): 431-4
Russo ME "Penicillin-aminoglycoside inactivation: another possible mechanism of interaction." Am J Hosp Pharm 37 (1980): 702-4
Thompson MI, Russo ME, Saxon BJ, Atkin-Thor E, Matsen JM "Gentamicin inactivation by piperacillin or carbenicillin in patients with end-stage renal disease." Antimicrob Agents Chemother 21 (1982): 268-72
Weibert R, Keane W, Shapiro F "Carbenicillin inactivation of aminoglycosides in patients with severe renal failure." Trans Am Soc Artif Intern Organs 22 (1976): 439-43

Ampicillin Injection Solution

Generic Name: ampicillin

Brand name: Ampicillin, Principen, Omnipen-N, Totacillin-N

Synonyms: Ampicillin

What is Ampicillin Injection Solution?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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