Amturnide and Eculizumab

• Generic Name: aliskiren / amlodipine / hydrochlorothiazide
• Dosage Forms: tablet, film coated
• Other Brand Names: Amturnide

Amturnide contains a combination of aliskiren, amlodipine, and hydrochlorothiazide. Aliskiren is an anti-hypertensive (blood pressure lowering) medication. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.

Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Amturnide is used to treat high blood pressure (hypertension).

Amturnide is usually given after other blood pressure medications have been tried without successful treatment of symptoms.

• Generic Name: eculizumab
• Dosage Forms: n.a.
• Other Brand Names: Soliris

Eculizumab is a monoclonal antibody. Eculizumab binds to proteins in the blood that can destroy red blood cells in people with genetic conditions that affect the natural defenses of red blood cells.

Eculizumab is used to prevent the breakdown of red blood cells in adults with paroxysmal nocturnal hemoglobinuria (PNH).

Eculizumab is also used to treat a rare chronic blood disease called atypical hemolytic uremic syndrome (aHUS) in adults and children who weigh at least 11 pounds (5 kilograms).

Eculizumab is also used to treat myasthenia gravis in adults.

Eculizumab is also used to treat neuromyelitis optica spectrum disorder (NMOSD) in adults.

Eculizumab is available only under a special program. You must be registered in the program and understand the risks and benefits of eculizumab.

Eculizumab may also be used for purposes not listed in this medication guide.