Amytal Sodium and Verapamil
Determining the interaction of Amytal Sodium and Verapamil and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking verapamil, tell your doctor if you also use amobarbital. You may need dose adjustments or special tests in order to safely take both medications together. You should monitor your blood pressure more closely for changes while taking verapamil whenever amobarbital is started or stopped. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Some barbiturates may significantly decrease serum verapamil concentrations and half-life, especially with oral dosage forms. The mechanism is induction of CYP450 3A4 first-pass metabolism of verapamil.
MANAGEMENT: Close observation for reduced verapamil effect is recommended if these drugs must be used together. Dose adjustments may be required. Patients should also be monitored for verapamil toxicity after the barbiturate is discontinued.
- Rutledge DR, Pieper JA, Mirvis DM "Effects of chronic phenobarbital on verapamil dispostion in humans." J Pharmacol Exp Ther 246 (1988): 7-13
Generic Name: amobarbital
Brand name: Amytal Sodium
Synonyms: n.a.
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Amytal Sodium-Verapamil Extended Release Capsules
- Amytal Sodium-Verapamil Extended Release Tablets
- Amytal Sodium-Verapamil Hydrochloride
- Amytal Sodium-Verapamil Hydrochloride PM
- Amytal Sodium-Verapamil Immediate-Release Tablets
- Amytal Sodium-Verapamil Injection
- Verapamil-An-DTPA
- Verapamil-Ana-Lex Cream
- Verapamil-Ana-Lex topical/rectal
- Verapamil-Anacaine
- Verapamil-Anacin
- Verapamil-Anacin Advanced Headache Formula