Anacin Aspirin Free and Cimetidine
Determining the interaction of Anacin Aspirin Free and Cimetidine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Animal studies and some limited human studies have suggested that cimetidine may decrease the potential hepatotoxic effects of acetaminophen. The mechanism may be related to reductions in the rate at which reactive intermediate metabolites are formed. Not all studies have confirmed the occurrence of this interaction. No alterations in dosage are necessary.
- Slattery JT, McRorie TI, Reynolds R, et al "Lack of effect of cimetidine on acetaminophen disposition in humans." Clin Pharmacol Ther 46 (1989): 591-7
- Dalhoff K, Poulsen HE "Inhibition of acetaminophen oxidation by cimetidine and the effects on glutathione and activated sulphate synthesis rates." Pharmacol Toxicol 73 (1993): 215-8
- Mitchell MC, Schenker S, Speeg KV "Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man." J Clin Invest 73 (1984): 383-91
- Vendemiale G, Altomare E, Trizio T, Leandro G, Manghisi OG, Albano O "Effect of acute and chronic cimetidine administration on acetaminophen metabolism in humans." Am J Gastroenterol 82 (1987): 1031-4
Generic Name: acetaminophen
Brand name: Actamin, Anacin AF, Bromo Seltzer, Children's Tylenol, Mapap, Tactinal, Tempra Quicklets, Tycolene, Tylenol, Vitapap, Acephen, Feverall, Apra, Elixsure Fever/Pain, Medi-Tabs, Q-Pap, Silapap Childrens, Children's Silapap, Febrol Solution, Triaminic Fever Reducer, Genapap, Tylenol Junior, Children's Tylenol Meltaways, Junior Tylenol Meltaways, Mapap Infants, Tylenol Infants, Ofirmev, Tylenol 8 Hour, Tylenol Arthritis Pain, Tylophen
Synonyms: Anacin AF
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Anacin Aspirin Free-Cimetidine Hydrochloride
- Anacin Aspirin Free-Cimetidine Injection
- Anacin Aspirin Free-Cimetidine Oral Solution
- Anacin Aspirin Free-Cimetidine Sodium Chloride
- Anacin Aspirin Free-Cimetidine Tablets
- Anacin Aspirin Free-Cimzia
- Cimetidine-Anadrol
- Cimetidine-Anadrol-50
- Cimetidine-Anafranil
- Cimetidine-Anagrelide
- Cimetidine-Anagrelide hydrochloride
- Cimetidine-Anakinra