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Anakinra and Enbrel (Etanercept Prefilled Syringes)

Determining the interaction of Anakinra and Enbrel (Etanercept Prefilled Syringes) and the possibility of their joint administration.

Check result:

Anakinra <> Enbrel (Etanercept Prefilled Syringes)

Relevance: 24.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using anakinra together with etanercept is not recommended. Combining these medications can increase the risk of serious infections. Contact your doctor immediately if you experience fever, chills, body aches, sore throat, muscle weakness, or other flu-like symptoms during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The use of an interleukin-1 (IL-1) blocker in combination with a tumor necrosis factor (TNF) blocker may increase the risk of neutropenia and serious infections, possibly due to additive immunosuppressive effects. In a clinical study, neutropenia occurred in 3% and serious infections in 7% of patients receiving the IL-1 blocker anakinra in combination with a TNF blocker (n=58). No added benefit has been observed with the combination relative to either agent alone.

MANAGEMENT: Concomitant use of an IL-1 blocker and a TNF blocker is not recommended.

References

"Product Information. Cimzia (certolizumab)." UCB Pharma Inc, Smyrna, GA.
"Product Information. Simponi (golimumab)." Centocor Inc, Malvern, PA.
"Product Information. Arcalyst (rilonacept)." Regeneron Pharmaceuticals Inc, Tarrytown, NY.
"Product Information. Ilaris (canakinumab)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Kineret (anakinra)." Amgen, Thousand Oaks, CA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Anakinra

Generic Name: anakinra

Brand name: Kineret

Synonyms: n.a.

What is Anakinra?

Enbrel (Etanercept Prefilled Syringes)

Generic Name: etanercept

Brand name: Enbrel, Enbrel Prefilled Syringe, Enbrel SureClick, Erelzi Prefilled Syringe, Erelzi Sensoready Pen, Enbrel Mini Prefilled Cartridge

Synonyms: Enbrel

What is Enbrel (Etanercept Prefilled Syringes)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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