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Anaprox-DS and Di-Gel Liquid

Determining the interaction of Anaprox-DS and Di-Gel Liquid and the possibility of their joint administration.

Check result:

Anaprox-DS <> Di-Gel Liquid

Relevance: 24.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Antacids and some oral aluminum, calcium, or magnesium containing preparations may decrease the gastrointestinal absorption of enteric-coated naproxen, which requires an acidic environment for dissolution. The proposed mechanism is an increase in gastric pH (i.e. decreased gastric acidity) produced by antacids. In patients treated with antacids, the possibility of a reduced or subtherapeutic response to enteric-coated naproxen should be considered. Concomitant use of these drugs is generally not recommended. Aluminum hydroxide and some magnesium-containing antacids have also been reported to reduce the absorption of regular naproxen. The interaction may be minimized by separating the times of administration by at least 2 hours.

References

Segre EJ, Sevelius H, Varady J "Effects of antacids on naproxen absorption." N Engl J Med 291 (1974): 582-3
Brogden RN, Heel RC, Speight TM, Avery GS "Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states." Drugs 18 (1979): 241-77

Anaprox-DS

Generic Name: naproxen

Brand name: Aleve, Anaprox-DS, Flanax Pain Reliever, Midol Extended Relief, Naprelan 500, Naprosyn, EC-Naprosyn, Naprelan 375, Flanax, Naprelan, Anaprox, Naproxen Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis

Synonyms: n.a.

What is Anaprox-DS?

Di-Gel Liquid

Generic Name: aluminum hydroxide / magnesium hydroxide / simethicone

Brand name: Di-Gel Liquid, Mylanta, Almacone, Gelusil, Mag-al Plus, Mi-Acid, Milantex, Mintox, Mylanta Maximum Strength, Rulox, Mylanta Fast Acting, Mylanta DS Fast Acting, Maalox Plus, Masanti DS, Masanti II, Masanti, Alamag Plus, Mi-Acid II, Almacone-2, Mintox Plus, Mylagen, Mylagen-II, Magaant, Ri-Mox Plus, Rulox Plus, Di-Gel, Ri-Gel II, Uni-Lan, Uni-Lan II, Urban, Urban DS, Maldroxal Plus, Maalox Plus Extra Strength, Tempo, Maalox Max, Maalox, Aldroxicon I, Aldroxicon II, Maalox Antacid Antigas Regular Strength, Mintox Extra Strength, Mintox Maximum Strength, Comfort Gel Original, Comfort Gel Extra Strength, Mylanta Maximum Strength Cherry, Maalox Max Wild Berry, Maalox Advanced Maximum Strength, Milantex Maximum Strength, Maalox Advanced Regular Strength, Geri-Lanta, Mag-al Plus XS, Mylanta Maximum Strength Vanilla Caramel, Mi-Acid Maximum Strength

Synonyms: n.a.

What is Di-Gel Liquid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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