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Androxy and Gengraf Capsules

Determining the interaction of Androxy and Gengraf Capsules and the possibility of their joint administration.

Check result:

Androxy <> Gengraf Capsules

Relevance: 15.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with fluoxymesterone may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with androgens or anabolic steroids may increase the blood concentrations of cyclosporine. The exact mechanism of interaction is unknown but may involve competitive inhibition of the CYP450 3A4 metabolism of cyclosporine. There have been case reports of transplant patients who developed cyclosporine toxicity following the addition of methyltestosterone or danazol. In addition, a pharmacokinetic study in one patient found that cyclosporine systemic exposure (AUC) increased 65% during coadministration with danazol, despite a reduction in cyclosporine dose. The interaction has not been reported with other androgens or anabolic steroids but may theoretically occur due to the structural similarities of these agents. Pharmacodynamically, there is also a potential for additive hepatotoxicity during coadministration, as both cyclosporine and androgens can have adverse effects on the liver.

MANAGEMENT: Caution is advised if cyclosporine is prescribed with androgens or anabolic steroids. Cyclosporine blood levels, renal function, and liver function tests should be monitored frequently and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of androgen dosage in patients who are stabilized on their cyclosporine regimen. Patients should be advised to notify their physician if they experience possible signs of cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions.

References

Wood P, Liu Yin JA "Oxymetholone hepatotoxicity enhanced by concomitant use of cyclosporin A in a bone marrow transplant patient." Clin Lab Haematol 16 (1994): 201-4
Moller BB, Ekelund B "Toxicity of cyclosporine during treatment with androgens." N Engl J Med 313 (1985): 1416
Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (part II)." Clin Pharmacokinet 19 (1990): 400-15
Ross WB, Roberts D, Griffin PJA, Salaman JR "Cyclosporin interaction with danazol and norethisterone." Lancet 1 (1986): 330
Goffin E, Pirson Y, Geubel A, de Strihou C "Cyclosporine-methyltestosterone interaction." Nephron 59 (1991): 174-5
Borras-Blasco J, Rosique-Robles JD, Peris-Marti J, Navarro-Ruiz J, Gonzalez-Delgado M, Conesa-Garcia V "Possible cyclosporin-danazol interaction in a patient with aplastic anaemia." Am J Hematol 62 (1999): 63-4
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50

Androxy

Generic Name: fluoxymesterone

Brand name: Androxy

Synonyms: n.a.

What is Androxy?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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