Anectine and Atropine and pralidoxime
Determining the interaction of Anectine and Atropine and pralidoxime and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Pralidoxime may reduce the effects of succinylcholine. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Oximes used in organophosphorous poisoning such as pralidoxime or obidoxime may antagonize the neuromuscular blocking effects of succinylcholine and mivacurium. Oximes reactivate acetylcholinesterase that has been inactivated by phosphorylation due to exposure to an organophosphorous nerve agent or insecticide, and the reactivated acetylcholinesterase then hydrolyzes excess acetylcholine resulting from the exposure to help restore impaired cholinergic neural function. Since succinylcholine and mivacurium are metabolized by plasma cholinesterases, patients with organophosphorous poisoning who have been treated with an oxime may exhibit accelerated reversal of the neuromuscular blocking effects of these agents relative to those who have not received an oxime.
MANAGEMENT: Neuromuscular effects should be monitored when succinylcholine or mivacurium is coadministered with an oxime.
- "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.
- Selden BS, Curry SC "Prolonged succinylcholine-induced paralysis in organophosphate insecticide poisoning." Ann Emerg Med 16 (1987): 215-7
Generic Name: succinylcholine
Brand name: Anectine, Quelicin
Synonyms: n.a.
Generic Name: atropine / pralidoxime
Brand name: ATNAA, DuoDote
Synonyms: Atropine and Pralidoxime
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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