Drug search by name

Anectine and Cytoxan

Determining the interaction of Anectine and Cytoxan and the possibility of their joint administration.

Check result:

Anectine <> Cytoxan

Relevance: 14.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using cyclophosphamide together with succinylcholine. Cyclophosphamide may increase the effects of succinylcholine. Contact your doctor immediately if your condition worsens or if you have breathing difficulty. You may need a dose adjustment if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Cyclophosphamide may increase the effects of succinylcholine. The mechanism is irreversible inhibition of plasma cholinesterase resulting in decreased metabolism of some neuromuscular blockers. Apnea has been associated with this drug combination. Reductions in cholinesterase levels of 35% to 70% have been reported. This effect may last for up to several weeks after administration of cyclophosphamide.

MANAGEMENT: Succinylcholine should probably be avoided in patients with low cholinesterase levels. Other patients should be closely monitored for excessive and prolonged neuromuscular blockade and ventilatory support should be available.

References

Zsigmond EK, Robins G "The effect of a series of anti-cancer drugs on plasma cholinesterase activity." Can Anaesth Soc J 19 (1972): 75-82
"Product Information. Anectine (succinylcholine)." Glaxo Wellcome, Research Triangle Park, NC.
Dillman JB "Safe use of succinylcholine during repeated anesthetics in a patient treated with cyclophosphamide." Anesth Analg 66 (1987): 351-3
Walker IR, Zapf PW, Mackay IR "Cyclophosphamide, cholinesterase and anaesthesia." Aust N Z J Med 2 (1972): 247-51

Anectine

Generic Name: succinylcholine

Brand name: Anectine, Quelicin

Synonyms: n.a.

What is Anectine?

Cytoxan

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: Cytoxan (Injection)

What is Cytoxan?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions