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Anectine and Forane

Determining the interaction of Anectine and Forane and the possibility of their joint administration.

Check result:

Anectine <> Forane

Relevance: 14.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using succinylcholine together with isoflurane can prolong the effects of succinylcholine. You should be closely monitored for prolonged breathing cessation and respiratory paralysis after use of isoflurane. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Inhalation anesthetics may potentiate the effects of nondepolarizing muscle relaxants. Long-acting muscle relaxants such as pancuronium and d-tubocurarine are more affected than other agents.

MANAGEMENT: The muscle relaxant dosage may need to be reduced when inhalation anesthetics are used, especially during longer procedures. In general, inhalation anesthetics should be administered only by health care providers specially trained in the use of these agents and in the care of anesthetized patients.

References

"Product Information. Ultane (sevoflurane)." Abbott Pharmaceutical, Abbott Park, IL.
Kronenfeld MA, Thomas SJ, Turndorf H "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology 65 (1986): 93-4
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Ramsey FM, White PA, Stullken EH, Allen LL, Roy RC "Enflurane potentiation of neuromuscular blockade by atracurium." Anesthesiology 57 (1982): a255
Cerner Multum, Inc. "Australian Product Information." O 0
Swen J, Rashkovsky OM, Ket JM, Koot HW, Hermans J, Agoston S "Interaction between nondepolarizing neuromuscular blocking agents and inhalational anesthetics." Anesth Analg 69 (1989): 752-5
Miller RD, Eger EI, Way WL, Stevens WC, Dolan WM "Comparative neuromuscular effects of forane and halothane alone and in combination with d-tubocurarine in man." Anesthesiology 35 (1971): 38-42
Duncalf D, Nagashima H, Hollinger I, Badola RP, Kaplan R, Foldes FF "Relaxation with ORG-NC45 during enflurane anesthesia." Anesthesiology 55 (1981): a203
Withington DE, Donati F, Bevan DR, Varin F "Potentiation of atracurium neuromuscular blockade by enflurane: time-course of effect." Anesth Analg 72 (1991): 469-73

Anectine

Generic Name: succinylcholine

Brand name: Anectine, Quelicin

Synonyms: n.a.

What is Anectine?

Forane

Generic Name: isoflurane

Brand name: Forane, Terrell

Synonyms: n.a.

What is Forane?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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