Antabuse and MetroGel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using medications like metroNIDAZOLE topical together with disulfiram may cause confusion and psychotic reactions such as delusions and hallucinations in some patients. You should generally not use metroNIDAZOLE topical if you have taken disulfiram within the last two weeks. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Use of a nitroimidazole in patients treated with disulfiram may result in psychotic reactions. The exact mechanism of interaction is unknown, but may involve additive effects on aldehyde dehydrogenase (ALDH) inhibition. The interaction has been reported with metronidazole. In one study, 6 of 29 hospitalized alcoholic patients who were treated with disulfiram (500 mg daily for one month, then 250 mg daily) and metronidazole (750 mg daily for one month, then 250 mg daily) developed acute psychoses or a confusional state, compared to none of the 29 patients receiving disulfiram alone. Five had paranoid delusions and three had visual and auditory hallucinations. Symptoms initially increased following withdrawal of the medications, but resolved slowly over two weeks and did not recur when disulfiram alone was restarted. No data are available for other nitroimidazoles or vaginally administered metronidazole.

MANAGEMENT: Nitroimidazole therapy should not be administered to patients who are taking disulfiram, or have taken it within the last two weeks.

Antabuse

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Antabuse?

MetroGel

Generic Name: metronidazole topical

Brand name: MetroCream, MetroGel, MetroGel Pump, MetroLotion, Noritate, Rosadan, MetroGel-Vaginal, Nuvessa, Vandazole

Synonyms: n.a.

What is MetroGel?