Antabuse and Tipranavir Oral Solution
Determining the interaction of Antabuse and Tipranavir Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using disulfiram together with tipranavir. Tipranavir capsules contain alcohol, which can produce severe reactions when taken with disulfiram. This can cause flushing, fast heartbeats, nausea, thirst, chest pain, vertigo, and low blood pressure. Be aware of the alcohol content of other common products such as cough and cold medicines, mouth washes, tonics, sauces, vinegars, and other food products. Alcohol in these products can also cause a reaction with disulfiram. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Tipranavir capsules contain alcohol, which can produce severe reactions when coadministered with disulfiram. The mechanism is inhibition of aldehyde dehydrogenase (ALDH) by disulfiram. Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'. Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.
MANAGEMENT: Concomitant use of tipranavir capsules and disulfiram should be avoided.
- Jones RO "Death following the ingestion of alcohol in an antabuse treated patient." Can Med Assoc J 60 (1949): 609-12
- "Product Information. Antabuse (disulfiram)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- van Ieperen L "Sudden death during disulfiram-ethanol reaction." S Afr Med J 66 (1984): 165
- Elenbaas RM "Drug therapy reviews: management of the disulfiram-alcohol reaction." Am J Hosp Pharm 34 (1977): 827-31
- "Product Information. Aptivus (tipranavir)." Boehringer-Ingelheim, Ridgefield, CT.
- Stoll D, King LE "Disulfiram-alcohol skin reaction to beer-containing shampoo." JAMA 244 (1980): 2045
Generic Name: tipranavir
Brand name: Aptivus
Synonyms: Tipranavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Antabuse-Tirofiban
- Antabuse-Tirofiban Intravenous
- Antabuse-Tirosint
- Antabuse-Tirosint-Sol
- Antabuse-Tisagenlecleucel
- Antabuse-Tisagenlecleucel Intravenous
- Tipranavir Oral Solution-Antagon
- Tipranavir Oral Solution-Antara
- Tipranavir Oral Solution-Anthrax vaccine
- Tipranavir Oral Solution-Anthrax Vaccine Adsorbed
- Tipranavir Oral Solution-Anthrax vaccine Intramuscular
- Tipranavir Oral Solution-Anti-Diarrheal Tablet