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Antabuse and Trezix

Determining the interaction of Antabuse and Trezix and the possibility of their joint administration.

Check result:

Antabuse <> Trezix

Relevance: 26.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Disulfiram may increase the cardiovascular and CNS-stimulant effects of caffeine. The mechanism may be related to inhibition of caffeine metabolism in liver microsomes. Patients should be advised to limit their caffeine intake while they are taking disulfiram, particularly if they are experiencing excessive irritability, nervousness or insomnia.

References

Beach CA, Mays DC, Guiler RC, et al "Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics." Clin Pharmacol Ther 39 (1986): 265-70

Antabuse

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Antabuse?

Trezix

Generic Name: acetaminophen / caffeine / dihydrocodeine

Brand name: Dvorah, Panlor Tablet, Trezix, Panlor DC, Panlor SS, Zerlor

Synonyms: n.a.

What is Trezix?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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