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Antabuse and Xanax

Determining the interaction of Antabuse and Xanax and the possibility of their joint administration.

Check result:

Antabuse <> Xanax

Relevance: 26.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Disulfiram may increase the blood levels and effects of ALPRAZolam. This can increase the risk of side effects including excessive drowsiness and breathing difficulties. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: The combination of disulfiram and benzodiazepines may increase CNS depression. The mechanism may relate to the inhibition of hepatic oxidation of benzodiazepines by disulfiram. Diazepam and chlordiazepoxide may interact with disulfiram to a greater extent than other benzodiazepines. However, the interaction has also been reported with temazepam, even though it is metabolized by glucuronidation.

MANAGEMENT: The benzodiazepine dosage may require reduction. Patients should be monitored for excessive and prolonged sedation.

References

Sellers EM, Giles HG, Greenblatt DJ, Naranjo CA "Differential effects on benzodiazepine disposition by disulfiram and ethanol." Arzneimittelforschung 30 (1980): 882-6
Hardman M, Biniwale A, Clarke CE "Temazepam toxicity precipitated by disulfiram." Lancet 344 (1994): 1231-2
MacLeod SM, Sellers EM, Giles HG, et al "Interaction of disulfiram with benzodiazepines." Clin Pharmacol Ther 24 (1978): 583-9

Antabuse

Generic Name: disulfiram

Brand name: Antabuse

Synonyms: n.a.

What is Antabuse?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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