Anticoagulant Sodium Citrate and Diclofenac and Misoprostol Tablets
Determining the interaction of Anticoagulant Sodium Citrate and Diclofenac and Misoprostol Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction is unknown. In twelve study subjects, coadministration of misoprostol with antacid reduced the bioavailability of misoprostol acid by 16% relative to fasting. Clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.
- Karim A, Rozek LF, Smith ME, Kowalski KG "Effects of food and antacid on oral absorption of misoprostol, a synthetic prostaglandin E1 analog." J Clin Pharmacol 29 (1989): 439-43
- "Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.
Generic Name: sodium citrate
Brand name:
Synonyms: n.a.
Generic Name: diclofenac / misoprostol
Brand name: Arthrotec
Synonyms: Diclofenac and misoprostol, Diclofenac and Misoprostol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Anticoagulant Sodium Citrate-Diclofenac Capsules
- Anticoagulant Sodium Citrate-Diclofenac Cream
- Anticoagulant Sodium Citrate-Diclofenac Delayed-Release Tablets
- Anticoagulant Sodium Citrate-Diclofenac epolamine
- Anticoagulant Sodium Citrate-Diclofenac Epolamine Patch
- Anticoagulant Sodium Citrate-Diclofenac Extended Release Tablets 100mg
- Diclofenac and Misoprostol Tablets-Antiflex
- Diclofenac and Misoprostol Tablets-Antifungal
- Diclofenac and Misoprostol Tablets-Antihemophilic and von Willebrand factor complex
- Diclofenac and Misoprostol Tablets-Antihemophilic Factor (Recombinant [Fc Fusion Protein])
- Diclofenac and Misoprostol Tablets-Antihemophilic Factor (Recombinant [Pegylated-aucl])
- Diclofenac and Misoprostol Tablets-Antihemophilic Factor (Recombinant [Pegylated])