Anticoagulant Sodium Citrate and Mycophenolate mofetil oral/injection
Determining the interaction of Anticoagulant Sodium Citrate and Mycophenolate mofetil oral/injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sodium citrate together with mycophenolate mofetil may decrease the effects of mycophenolate mofetil. You should separate the administration times of the medications by at least two hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of mycophenolic acid. The exact mechanism of interaction is unknown but may involve chelation with polyvalent ions in antacids or enhanced drug solubility induced by an increase in gastric pH, or both. The interaction has been reported with magnesium/aluminum-containing antacids.
MANAGEMENT: Patients treated with oral mycophenolic acid who require an antacid or antacid-containing preparation (e.g., didanosine buffered tablets or pediatric oral solution) should separate the administration times of the medications by at least two hours.
- "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals, East Hanover, NJ.
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
- Lipsky JJ "Mycophenolate mofetil." Lancet 348 (1996): 1357-9
- Bullingham R, Shah J, Goldblum R, Schiff M "Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients." Br J Clin Pharmacol 41 (1996): 513-6
Generic Name: sodium citrate
Brand name:
Synonyms: n.a.
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Anticoagulant Sodium Citrate-Mycophenolate Mofetil Tablets
- Anticoagulant Sodium Citrate-Mycophenolate sodium
- Anticoagulant Sodium Citrate-Mycophenolate Suspension
- Anticoagulant Sodium Citrate-Mycophenolate Tablets
- Anticoagulant Sodium Citrate-Mycophenolate Tablets Delayed Release
- Anticoagulant Sodium Citrate-Mycophenolic acid
- Mycophenolate mofetil oral/injection-Antiflex
- Mycophenolate mofetil oral/injection-Antifungal
- Mycophenolate mofetil oral/injection-Antihemophilic and von Willebrand factor complex
- Mycophenolate mofetil oral/injection-Antihemophilic Factor (Recombinant [Fc Fusion Protein])
- Mycophenolate mofetil oral/injection-Antihemophilic Factor (Recombinant [Pegylated-aucl])
- Mycophenolate mofetil oral/injection-Antihemophilic Factor (Recombinant [Pegylated])