Antiflex and Wellbutrin Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Orphenadrine may increase the blood levels and effects of buPROPion. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience seizures, anxiety, tremor, insomnia, hallucinations, confusion, and/or difficulty concentrating, as these may be signs and symptoms of excessive buPROPion levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors or substrates of CYP450 2B6 may increase the plasma concentrations of bupropion, which is primarily metabolized by the isoenzyme. The interaction has been demonstrated with clopidogrel and ticlopidine, both of which are CYP450 2B6 inhibitors. In 12 healthy male volunteers, administration of a single 150 mg dose of bupropion in combination with clopidogrel (75 mg orally once daily for 4 days) resulted in a 40% increase in bupropion peak plasma concentration (Cmax) and 60% increase in systemic exposure (AUC) compared to administration of bupropion alone. Additionally, the AUC of the hydroxybupropion metabolite decreased by 52% and the AUC ratio of hydroxybupropion to bupropion decreased by 68% with clopidogrel, while oral clearance decreased by 26%. Similarly, pretreatment with ticlopidine (250 mg orally twice daily for 4 days) increased the Cmax and AUC of bupropion (150 mg single oral dose) by 38% and 85%, respectively, compared to administration of bupropion alone. The AUC of the hydroxybupropion metabolite decreased by 84% and the AUC ratio of hydroxybupropion to bupropion decreased by 90% with ticlopidine, while oral clearance decreased by 36%.

MANAGEMENT: Caution is advised if bupropion is prescribed with a substrate or inhibitor of CYP450 2B6. Pharmacologic response to bupropion should be monitored more closely whenever a CYP450 2B6 substrate or inhibitor is added to or withdrawn from therapy, and the bupropion dosage adjusted as necessary. Patients should be advised to contact their physician if they experience potential symptoms of bupropion toxicity such as agitation, anxiety, tremor, insomnia and seizures, or neuropsychiatric symptoms such as delusions, hallucinations, psychosis, impaired concentration, paranoia and confusion.

Antiflex

Generic Name: orphenadrine

Brand name: Norflex, Banflex, Orphenate, Flexoject, Flexon, Mio-Rel, Myolin, Orfro, Norflex Injectable, Antiflex

Synonyms: Antiflex (Injection)

What is Antiflex?

Wellbutrin Tablets

Generic Name: bupropion

Brand name: Aplenzin, Buproban, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, Zyban Advantage Pack, Budeprion XL

Synonyms: Wellbutrin

What is Wellbutrin Tablets?