Antinaus 50 and Proamatine
Determining the interaction of Antinaus 50 and Proamatine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using promethazine together with midodrine can increase the side effects of promethazine. Contact your doctor if you experience tension, restlessness, insomnia, and anxiety. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data suggest that midodrine may potentiate the risk of akathisia associated with promethazine. The mechanism is unknown but may involve competitive inhibition of CYP450 2D6 metabolism. In nine healthy volunteers, six experienced akathisia after receiving a single 10 mg oral dose of midodrine followed 60 minutes later by a 25 mg intravenous dose of promethazine, compared to four after receiving promethazine and placebo. No subject experienced akathisia following midodrine alone. The severity of akathisia was also significantly greater with the combination than with promethazine alone.
MANAGEMENT: Patients treated with midodrine and promethazine in combination should be monitored for signs and symptoms of akathisia such as tension, restlessness, insomnia, and anxiety. One or both drugs may need to be discontinued if akathisia occurs.
- Platts SH, Shi SJ, Meck JV "Akathisia with combined use of midodrine and promethazine." JAMA 295 (2006): 2000-1
Generic Name: promethazine
Brand name: Phenadoz, Promethegan, Phenergan
Synonyms: n.a.
Generic Name: midodrine
Brand name: Proamatine, Orvaten
Synonyms: Proamatine (Oral), ProAmatine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Antinaus 50-Probalan
- Antinaus 50-Probenecid
- Antinaus 50-Probenecid and colchicine
- Antinaus 50-Probenecid Tablets
- Antinaus 50-Probiotic Formula (Bacillus Coagulans)
- Antinaus 50-Probucol
- Proamatine-Antispasmodic
- Proamatine-Antithrombin
- Proamatine-Antithrombin alfa
- Proamatine-Antithrombin III (Human)
- Proamatine-Antithymocyte Globulin (Equine)
- Proamatine-Antithymocyte globulin rabbit Intravenous