Antithrombin alfa and Ziac

• Generic Name: antithrombin (recombinant)
• Dosage Forms: n.a.
• Other Brand Names: ATryn

Prevention of perioperative and peripartum thromboembolism in patients with congenital antithrombin III deficiency; designated an orphan drug by FDA for use in these conditions.

Short-term thromboprophylaxis with an appropriate anticoagulant recommended in patients with congenital antithrombin III deficiency during high-risk situations (e.g., surgery, pregnancy, postpartum period); antithrombin III concentrates may be used when anticoagulant therapy is neither feasible (e.g., due to a bleeding risk) nor sufficient.

Not indicated for treatment of thromboembolic events.

Has been used for management of heparin resistance during cardiopulmonary bypass (CPB).

May reduce requirements for fresh frozen plasma and additional heparin during CPB.

• Generic Name: bisoprolol / hydrochlorothiazide
• Dosage Forms: tablet, film coated
• Other Brand Names: Ziac

Ziac contains a combination of hydrochlorothiazide and bisoprolol. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Bisoprolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

Ziac is used to treat high blood pressure (hypertension).

Ziac may also be used for purposes not listed in this medication guide.